Chaetoglobosin E is a potent ferroptosis inducer that targets and downregulates GPX4 expression in human tumor cell lines. It exhibits significant cytotoxic effects, with IC50 values of 9.14 μM against MDA-MB231 cells and 7.47 μM against A549 cells. The compound elevates intracellular Fe2+ levels and increases the lipid peroxidation marker malondialdehyde (MDA), resulting in mitochondrial alterations and the induction of ferroptosis. Chaetoglobosin E serves as a valuable tool for cancer research and the study of ferroptosis mechanisms.
Chaetoglobosin E is a potent ferroptosis inducer that targets and downregulates GPX4 expression in human tumor cell lines. It exhibits significant cytotoxic effects, with IC50 values of 9.14 μM against MDA-MB231 cells and 7.47 μM against A549 cells. The compound elevates intracellular Fe2+ levels and increases the lipid peroxidation marker malondialdehyde (MDA), resulting in mitochondrial alterations and the induction of ferroptosis. Chaetoglobosin E serves as a valuable tool for cancer research and the study of ferroptosis mechanisms.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
