Fig. 1 · Structure
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CHAPS hydrate
Ionic Detergent/Micelle Forming Agent
CHAPS hydrate is a zwitterionic detergent derived from cholic acid, functioning primarily as a micelle-forming agent. It offers weak cationic or nonionic surfactant properties, undergoing micellization to form hydrophilic aggregates that are sensitive to temperature changes. CHAPS hydrate is instrumental in stabilizing mononucleosomes across various ionic strengths, facilitating histone core sliding along DNA, and solubilizing Tamm‑Horsfall protein to improve urinary exosome isolation. This reagent is widely employed in the recovery of native folded fusion proteins, enhancing GST fusion protein binding capacity, and maintaining protein activity during membrane protein research, although it is ineffective for refolding proteins denatured by strong agents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 331717-45-4 |
| Applications | Ionic Detergent/Micelle Forming Agent |
| Formula | C32H60N2O8S |
| Molecular Weight | 632.89 |
| SMILES | O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(NCCC[N+](C)(C)CCCS(=O)([O-])=O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.