Fig. 1 · Structure
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CHK-336
LDHA Inhibitor
CHK-336 is a potent LDHA inhibitor, exhibiting an IC50 of less than 1 nM. It effectively reduces lactate production in mouse hepatocytes, making it a valuable tool for studying metabolic disorders such as hyperoxaluria. This compound facilitates exploration of LDHA's role in various biological processes and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2743436-86-2 |
| Applications | LDHA Inhibitor |
| Formula | C24H20F2N4O4S2 |
| Molecular Weight | 530.57 |
| SMILES | O=C(C1=CSC(N2N=C(C(CC3=CC=C(S(=O)(N)=O)C(F)=C3)=C2CC4CC4)C5=CC=C(F)C=C5)=N1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.