Fig. 1 · Structure
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Chlorproguanil hydrochloride
Antimalarial
Chlorproguanil hydrochloride is an antimalarial compound that acts primarily by inhibiting dihydrofolate reductase, leading to disrupted nucleotide synthesis in Plasmodium species. This drug functions as a chlorinated derivative of chloroguanide and demonstrates significant activity against malaria parasites. It is utilized in research to explore antimalarial mechanisms and in the development of combination therapies for malaria treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 6001-93-0 |
| Applications | Antimalarial |
| Formula | C11H16Cl3N5 |
| Molecular Weight | 324.64 |
| SMILES | ClC1=CC=C(NC(NC(NC(C)C)=N)=N)C=C1Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.