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Chlorproguanil

Antifolate

Chlorproguanil is an antifolate that inhibits dihydrofolate reductase, demonstrating an IC50 of 4.68 μM against Plasmodium falciparum female gamete formation. This compound is primarily used in malaria research, providing insights into antimalarial mechanisms and potential therapeutic strategies. Its inhibitory effects on gametocyte development make it a valuable tool for studying Plasmodium biology and the development of malaria interventions.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	537-21-3
Applications	Antifolate
Formula	C₁₁H₁₅Cl₂N₅
Molecular Weight	288.18
SMILES	ClC1=CC=C(C=C1Cl)NC(=N)NC(=N)NC(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.