Fig. 1 · Structure
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CI-988
CCK2R Antagonist
CI-988 is a potent and selective antagonist of the cholecystokinin 2 receptor (CCK2R), exhibiting an IC50 of 1.7 nM in mouse cortex assays. Demonstrating over 1600-fold selectivity for CCK2 over the CCK1 receptor, CI-988 has been shown to possess anxiolytic and anti-tumor properties. This compound is valuable for research into therapeutic applications in anxiety disorders and cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 130332-27-3 |
| Applications | CCK2R Antagonist |
| Formula | C35H42N4O6 |
| Molecular Weight | 614.73 |
| Synonyms | PD134308 |
| SMILES | OC(CCC(N[C@H](C1=CC=CC=C1)CNC([C@](CC2=CNC3=C2C=CC=C3)(C)NC(OC4[C@H]5C[C@H](C6)C[C@@H]4C[C@H]6C5)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.