Fig. 1 · Structure
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Cipargamin enantiomer
Antimalarial Agent
Cipargamin enantiomer is a spirotetrahydro β-carboline that serves as an effective inhibitor of Plasmodium falciparum, the causative agent of malaria. This compound demonstrates significant antiplasmodial activity against various strains, with an IC50 of 77 nM for the NF54 strain. Additionally, Cipargamin enantiomer exhibits low intrinsic clearance in mouse and human liver microsomes and does not inhibit CYP2C9. It is a valuable tool for research focused on malaria and the development of antimalarial therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1193314-24-7 |
| Applications | Antimalarial Agent |
| Formula | C19H14Cl2FN3O |
| Molecular Weight | 390.24 |
| Synonyms | NITD609 enantiomer; KAE609 enantiomer |
| SMILES | FC1=C(Cl)C=C(NC2=C3C[C@@H](C)N[C@]2(C4=C(C=CC(Cl)=C4)N5)C5=O)C3=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.