Ciprofloxacin prodrug-1 is an activated prodrug targeting β-lactamase-producing bacteria. It demonstrates potent antibacterial activity, with a minimum inhibitory concentration (MIC) of 63 nM against β-lactamase-expressing strains. Upon hydrolysis by β-lactamase, Ciprofloxacin prodrug-1 releases the active antibiotic Ciprofloxacin, effectively inhibiting DNA gyrase activity. This compound is valuable for investigating infections caused by drug-resistant bacteria, particularly uropathogenic Escherichia coli.
Ciprofloxacin prodrug-1 is an activated prodrug targeting β-lactamase-producing bacteria. It demonstrates potent antibacterial activity, with a minimum inhibitory concentration (MIC) of 63 nM against β-lactamase-expressing strains. Upon hydrolysis by β-lactamase, Ciprofloxacin prodrug-1 releases the active antibiotic Ciprofloxacin, effectively inhibiting DNA gyrase activity. This compound is valuable for investigating infections caused by drug-resistant bacteria, particularly uropathogenic Escherichia coli.
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