Fig. 1 · Structure
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cis-INCB3344
Isomer
Cis-INCB3344 is the isomer of INCB3344 and serves as an experimental control in research. INCB3344 is recognized as a potent and selective antagonist of the CCR2 receptor, exhibiting binding antagonism with IC50 values of 5.1 nM for human CCR2 and 9.5 nM for mouse CCR2. Additionally, it demonstrates effective chemotaxis inhibition with IC50 values of 3.8 nM for human CCR2 and 7.8 nM for mouse CCR2. This compound is useful in studies focusing on inflammatory responses and related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1285539-85-6 |
| Applications | Isomer |
| Formula | C29H34F3N3O6 |
| Molecular Weight | 577.59 |
| SMILES | O=C(NCC(N[C@H]1CN([C@@H]2CC[C@](C3=CC=C(OCO4)C4=C3)(O)CC2)C[C@@H]1OCC)=O)C5=CC=CC(C(F)(F)F)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.