cis-Pralsetinib

Catalog No.: A21586

RET inhibitor

cis-Pralsetinib

cis-Pralsetinib Chemical Structure

CAS NO. 2097132-93-7

cis-Pralsetinib (cis-BLU-667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50s ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.

Availability: In stock

Package Price Qty
5 mg
$117.00
10 mg
$202.00
50 mg
$598.00
100 mg
$1,196.00
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Biological Activity

cis-Pralsetinib (cis-BLU-667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50s ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.74 mL 93.7 mL 187.41 mL
0.5 mM 3.75 mL 18.74 mL 37.48 mL
1 mM 1.87 mL 9.37 mL 18.74 mL
5 mM 0.37 mL 1.87 mL 3.75 mL

*The above data is based on the productmolecular weight 533.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21586
Actions Inhibitor
CAS No. 2097132-93-7
Formula C27H32FN9O2
M. Wt 533.6
Purity >98%
Synonyms cis-BLU-667, BLU667, BLU 667
SMILES O=C([[email protected]@]1(OC)CC[[email protected]@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[[email protected]](C4=CC=C(N5N=CC(F)=C5)N=C4)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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