Fig. 1 · Structure
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cis-VZ185
PROTAC
cis-VZ185 is a VHL-based PROTAC that targets and facilitates the degradation of BRD9 and BRD7 proteins. This compound demonstrates efficient and rapid degradation efficiency, making it a valuable tool for studies involving epigenetic regulation and the functional role of bromodomain proteins. cis-VZ185 is suitable for research applications focused on targeted protein degradation and the exploration of novel therapeutic strategies in cancer and other diseases linked to aberrant BRD protein expression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2306193-98-4 |
| Applications | PROTAC |
| Formula | C53H67FN8O8S |
| Molecular Weight | 995.21 |
| SMILES | CN1C=C(C2=CC=NC=C2C1=O)C3=CC(OC)=C(CN4CCN(CCCCCOC5=C(CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@@H](O)C6)=O)C=CC(C8=C(N=CS8)C)=C5)CC4)C(OC)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.