Fig. 1 · Structure
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Clociguanil
Antimalarial Agent
Clociguanil is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 of 55.6 nM, primarily utilized as an antimalarial agent. In addition to its antimalarial properties, Clociguanil exhibits sympathomimetic and antiarrhythmic actions, making it suitable for various research applications in parasitology and cardiovascular studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3378-93-6 |
| Applications | Antimalarial Agent |
| Formula | C12H15Cl2N5O |
| Molecular Weight | 316.19 |
| Synonyms | BRL 50216 |
| SMILES | NC1=NC(N)=NC(C)(N1OCC2=CC=C(C(Cl)=C2)Cl)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.