Fig. 1 · Structure

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Clozapine dihydrochloride

D2 Antagonist

Clozapine dihydrochloride is an antipsychotic compound that primarily functions as a dopamine D2 receptor antagonist, exhibiting a Ki of 75 nM. It demonstrates significant affinity for muscarinic M1 and serotonin 5HT2A receptors, with Kis of 9.5 nM and 4 nM, respectively. Additionally, Clozapine acts as a potent and selective agonist at the muscarinic M4 receptor, with an EC50 of 11 nM. This compound is crucial for research into schizophrenia and related neuropsychiatric disorders.

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Specifications

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 2711603-38-0
Applications D2 Antagonist
Formula C18H21Cl3N4
Molecular Weight 399.75
Synonyms HF 1854 dihydrochloride
SMILES
CN1CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1.Cl.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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