Fig. 1 · Structure
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Clozapine hydrochloride
Antipsychotic Agent
Clozapine hydrochloride is an antipsychotic agent primarily targeting dopamine D2 receptors, where it acts as a potent antagonist with a Ki value of 75 nM. This compound also exhibits strong inhibitory activity against muscarinic M1 and serotonin 5HT2A receptors, with Kis of 9.5 nM and 4 nM, respectively. Additionally, clozapine hydrochloride serves as a selective agonist for the muscarinic M4 receptor, demonstrating an EC50 of 11 nM. This profile makes clozapine hydrochloride valuable for research related to schizophrenia and other neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 54241-01-9 |
| Applications | Antipsychotic Agent |
| Formula | C18H20Cl2N4 |
| Molecular Weight | 363.28 |
| Synonyms | HF 1854 hydrochloride |
| SMILES | CN1CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.