Fig. 1 · Structure
Documents & Downloads
Clozapine N-oxide dihydrochloride
DREADD Activator
Clozapine N-oxide dihydrochloride is a selective agonist for designer receptors exclusively activated by designer drugs (DREADDs), specifically targeting hM3Dq and hM4Di. This compound plays a crucial role in neuronal circuit manipulation for experimental purposes. It is notable for its inability to cross the blood-brain barrier, making it useful for in vivo studies to modulate neuronal activity without central nervous system effects. Clozapine N-oxide dihydrochloride is integral in research applications related to neuroscience, enabling the dissection of gene function and behavior in animal models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2250025-93-3 |
| Applications | DREADD Activator |
| Formula | C18H21Cl3N4O |
| Molecular Weight | 415.74 |
| SMILES | C[N+]1([O-])CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.