Fig. 1 · Structure
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CM398
Sigma-2 Receptor Ligand
CM398 is a selective sigma-2 receptor ligand that demonstrates a high binding affinity (Ki = 0.43 nM) while maintaining a 1000-fold selectivity over the sigma-1 receptor. In addition to its primary target, CM398 exhibits appreciable affinity for dopamine (Ki = 32.90 nM) and serotonin (Ki = 244.2 nM) transporters. This compound has shown promising anti-inflammatory and analgesic properties in preclinical studies, specifically within the formalin model of inflammatory pain in mice, making it a valuable tool for research in pain management and neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1121931-70-1 |
| Applications | Sigma-2 Receptor Ligand |
| Formula | C23H29N3O3 |
| Molecular Weight | 395.49 |
| SMILES | O=C1N(C)C2=C(N1CCCCN3CC4=CC(OC)=C(C=C4CC3)OC)C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.