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CMI-392

Catalog No.: A76516
5-Lipoxygenese/PAF Receptor Antagonist
CMI-392 is a dual inhibitor of 5-lipoxygenase and a platelet-activating factor (PAF) receptor antagonist, exhibiting IC50 values of 100 nM and 10 nM, respectively. This compound demonstrates significant anti-inflammatory activities by modulating leukotriene synthesis and PAF signaling pathways. CMI-392 is valuable for research applications focused on inflammatory diseases and related therapeutic targets.
CMI-392 193739-23-0 5-Lipoxygenese/PAF Receptor Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCMI-392 is a dual inhibitor of 5-lipoxygenase and a platelet-activating factor (PAF) receptor antagonist, exhibiting IC50 values of 100 nM and 10 nM, respectively. This compound demonstrates significant anti-inflammatory activities by modulating leukotriene synthesis and PAF signaling pathways. CMI-392 is valuable for research applications focused on inflammatory diseases and related therapeutic targets.
Product Information
Catalog NumA76516
FormulaC31H37ClN2O8S
Molecular Weight633.15
CAS Number193739-23-0
SMILESO=C(NCC1=CC([C@H]2O[C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC2)=CC(OC)=C1OCCSC4=CC=C(Cl)C=C4)N(O)C
SynonymsLDP-392
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Metabolism > Lipoxygenase