Fig. 1 · Structure
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CMPD-39
USP30 Inhibitor
CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30, exhibiting an IC50 of approximately 20 nM and demonstrating high selectivity against other deubiquitinating enzymes. This compound effectively inhibits the deubiquitinating activity of USP30, leading to enhanced ubiquitination of mitochondrial proteins such as TOMM20 and SYNJ2BP. CMPD-39 promotes the accumulation of phospho-ubiquitin, thereby facilitating both mitochondrial and peroxisomal autophagy. Additionally, it has shown the potential to significantly restore mitochondrial function in dopaminergic neurons derived from patients with Parkinson's disease, making it a valuable tool for research into neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2242582-40-5 |
| Applications | USP30 Inhibitor |
| Formula | C26H28FN3O4S |
| Molecular Weight | 497.58 |
| SMILES | CC(C)(C)NS(=O)(C1=CC=C(C=C1)NC([C@@H](NC(C2=CC=C(C=C2)F)=O)CC3=CC=CC=C3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.