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Conantokin-T

Catalog No.: A67244
NMDA Antagonist Peptide
Conantokin-T is a γ-carboxyglutamate-containing peptide that acts as an NMDA receptor antagonist, exhibiting an IC50 value of 2 μM. This compound inhibits NMDA receptor-mediated calcium influx in central nervous system neurons, making it a valuable tool for studying synaptic transmission and neurotoxicity. Derived from the venom of the fish-hunting cone snail, Conus tulipa, Conantokin-T is useful in research applications related to neuropharmacology and neurological disorders.
Conantokin-T 127476-26-0 NMDA Antagonist Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionConantokin-T is a γ-carboxyglutamate-containing peptide that acts as an NMDA receptor antagonist, exhibiting an IC50 value of 2 μM. This compound inhibits NMDA receptor-mediated calcium influx in central nervous system neurons, making it a valuable tool for studying synaptic transmission and neurotoxicity. Derived from the venom of the fish-hunting cone snail, Conus tulipa, Conantokin-T is useful in research applications related to neuropharmacology and neurological disorders.
Product Information
Catalog NumA67244
FormulaC110H175N31O45S
Molecular Weight2683.81
CAS Number127476-26-0
Sequence shorteningGE-{Gla}-{Gla}-YQKML-{Gla}-NLR-{Gla}-AEVKKNA-NH2
SMILES[C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CCC(O)=O)=O)CC(C(O)=O)C(O)=O)=O)CC(C(O)=O)C(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(N)=O)=O)CCCCN)=O)CCCCN)=O)[C@H](C)C)=O)CCC(O)=O)=O)C)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CC(N)=O)=O)CC(C(O)=O)C(O)=O)=O)CC(C)C)=O)CCSC)=O)CCCCN)=O)CCC(N)=O)=O
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