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Conatumumab
Conatumumab (AMG 655) is a human monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2), displaying high affinity with dissociation constants (Kd) of 1 nM for the long form of DR5 and 0.8 nM for the short form. This antibody functions by inducing apoptosis through caspase activation, making it highly relevant for cancer research applications.
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Biological Activity
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 896731-82-1 |
| Molecular Weight | 144960 |
| Synonyms | AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.