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COOEt-bicyclo2.2.2octane-CHO

PROTAC Linker

COOEt-bicyclo[2.2.2]octane-CHO is a specialized PROTAC linker that facilitates the conjugation of E3 ligase ligands with SMARCA2 ligands. This compound plays a critical role in developing PROTAC SMARCA2 degrader-6, enabling targeted degradation of SMARCA2 proteins. Its unique structure enhances the efficiency of protein modulation strategies, making it suitable for applications in cancer research and drug discovery focused on proteolysis-targeting chimera technologies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	959958-67-9
Applications	PROTAC Linker
Formula	C₁₂H₁₈O₃
Molecular Weight	210.27
SMILES	O=C(OCC)C(CC1)(CC2)CCC12C=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.