Fig. 1 · Structure
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Coumberone
AKR1C Isoforms Substrate
Coumberone is a selective substrate for all AKR1C isoforms, functioning as a metabolic fluorogenic probe. It can be enzymatically reduced by the four members of the AKR1C family into the fluorescent product coumberol. This compound is useful in studying the catalytic activities and pharmacological roles of AKR1C enzymes in various biological contexts. Its fluorescent properties enable sensitive detection and quantitative analysis in research applications related to enzyme kinetics and metabolic profiling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 878019-47-7 |
| Applications | AKR1C Isoforms Substrate |
| Formula | C22H19NO3 |
| Molecular Weight | 345.39 |
| SMILES | O=C1OC2=C(C(C(C3=CC=CC=C3)=O)=C1)C=C4C5=C2CCCN5CCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.