Fig. 1 · Structure
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CWHM-1008
Antimalarial Agent
CWHM-1008 is a potent, orally active antimalarial agent that demonstrates remarkable efficacy with EC50 values of 46 nM against sensitive Plasmodium falciparum 3D7 strains and 21 nM against drug-resistant Dd2 strains. This compound highlights significant potential for the treatment of malaria, particularly in cases involving resistant parasites. Its targeted mechanism and strong biological activity make it a valuable tool for researchers studying antimalarial drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2362539-97-5 |
| Applications | Antimalarial Agent |
| Formula | C22H26F3N3O |
| Molecular Weight | 405.46 |
| SMILES | C[C@H](NC([C@H]1CNC[C@@H]1C2=CC=C(C(F)(F)F)C=C2)=O)C3=CC=C(N(C)C)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.