Cyclooctyne-O-amido-PEG2-PFP ester is a non-cleavable linker designed for antibody-drug conjugates (ADCs), utilizing a 2-unit polyethylene glycol (PEG) structure. This compound serves as a versatile click chemistry reagent, possessing an alkyne group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing biomolecules. Its application is critical for the development of targeted therapies, enhancing the delivery and efficacy of cytotoxic agents in ADC formulations.
Cyclooctyne-O-amido-PEG2-PFP ester is a non-cleavable linker designed for antibody-drug conjugates (ADCs), utilizing a 2-unit polyethylene glycol (PEG) structure. This compound serves as a versatile click chemistry reagent, possessing an alkyne group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing biomolecules. Its application is critical for the development of targeted therapies, enhancing the delivery and efficacy of cytotoxic agents in ADC formulations.
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