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Cyclosporin A-Derivative 1

Catalog No.: A64603
Cyclosporin A Crystalline Intermediate
Cyclosporin A-Derivative 1 is a crystalline intermediate of cyclosporin A that functions primarily by inhibiting calcineurin through binding to cyclophilin. This compound exhibits significant immunosuppressive activity, making it valuable in research related to transplantation, autoimmune diseases, and T-cell signaling. Its utility in studying the mechanisms of immune modulation further enhances its relevance in pharmacological investigations.
Cyclosporin A-Derivative 1 1487360-85-9 Cyclosporin A Crystalline Intermediate
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1mg
$95.00
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5mg
$235.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCyclosporin A-Derivative 1 is a crystalline intermediate of cyclosporin A that functions primarily by inhibiting calcineurin through binding to cyclophilin. This compound exhibits significant immunosuppressive activity, making it valuable in research related to transplantation, autoimmune diseases, and T-cell signaling. Its utility in studying the mechanisms of immune modulation further enhances its relevance in pharmacological investigations.
Product Information
Catalog NumA64603
FormulaC65H118BF4N11O14
Molecular Weight1364.50
CAS Number1487360-85-9
SequenceLeu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}
Sequence shorteningLVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}
SMILESF[B-](F)(F)F.C/C=C/C[C@@H](C)[C@@H](OC(C)=O)[C@@H](C(N[C@@H](CC)C(N(C)CC(OC)=O)=O)=O)N(C)C([C@H](C(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N(C)C([C@H](C(C)C)NC([C@@H](NC)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O.[H+]
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Immunology & Inflammation > Cyclophilin