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Cyclothialidine B

DNA Helicase Inhibitor

Cyclothialidine B is a selective inhibitor of Escherichia coli DNA helicases, exhibiting an IC50 of 0.7 μM. This compound is valuable for studying the mechanisms of DNA unwinding and replication processes in bacterial systems. It serves as a useful tool for research in molecular biology and genetic studies, particularly in the context of antimicrobial drug development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	194276-76-1
Applications	DNA Helicase Inhibitor
Formula	C₂₅H₃₃N₅O₁₁S
Molecular Weight	611.62
SMILES	O=C(N[C@@H](CSCC1=C(O)C=C(O)C=C1C(OC2)=O)C(N[C@@H](C)C(O)=O)=O)[C@H]2NC([C@H]3N(CC[C@H]3O)C([C@@H](N)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.