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Cyclothialidine

DNA Gyrase Inhibitor

Cyclothialidine is a potent inhibitor of DNA gyrase, a key enzyme involved in DNA replication and maintenance. Isolated from Streptomyces filipinensis NR0484, this compound exhibits significant antibacterial activity by obstructing the function of gyrase, leading to bacterial cell death. Cyclothialidine serves as a valuable tool in microbiological research and drug development aimed at addressing bacterial resistance and exploring the mechanisms of DNA manipulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	147214-63-9
Applications	DNA Gyrase Inhibitor
Formula	C₂₆H₃₅N₅O₁₂S
Molecular Weight	641.65
Synonyms	Ro 09-1437
SMILES	O=C(N[C@@H](CSCC1=C(O)C=C(O)C(C)=C1C(OC2)=O)C(N[C@@H](C)C(O)=O)=O)[C@H]2NC([C@H]3N(CC[C@H]3O)C([C@@H](N)CO)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.