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Cystemustine

DNA Inhibitor

Cystemustine is a chloroethyl nitrosourea (CENU) that acts as a DNA inhibitor through the formation of DNA cross-links. This mechanism disrupts tumor cell proliferation and induces cytotoxic effects by interfering with the cell cycle, promoting cell re-differentiation, and altering phospholipid metabolism. Cystemustine demonstrates significant anti-tumor efficacy and a relatively short plasma half-life in murine models. This compound is applicable in research focused on various malignant tumors, including melanoma, glioma, renal cancer, head and neck cancer, and colorectal cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	79955-36-5
Applications	DNA Inhibitor
Formula	C₆H₁₂ClN₃O₄S
Molecular Weight	257.70
SMILES	CS(CCNC(N(N=O)CCCl)=O)(=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.