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Integrin

Integrin inhibitors block the heterodimeric adhesion receptors that link the extracellular matrix to the cytoskeleton. Each integrin pairs one alpha and one beta subunit, and signals pass across the membrane in both directions. Many integrins recognize the arginine-glycine-aspartate (RGD) sequence, first identified as the cell attachment site of fibronectin. RGD (Arg-Gly-Asp) Peptides and the cyclic peptide cilengitide compete for this site on αvβ3 and αvβ5. Firategrast antagonizes α4β1 and α4β7, integrins involved in leukocyte trafficking. Tirofiban hydrochloride hydrate blocks the platelet integrin αIIbβ3, also known as glycoprotein IIb/IIIa. Obtustatin, a snake venom disintegrin, selectively inhibits the collagen receptor α1β1.

2 Items

  • Leukadherin 1
    Cat. No.
    A13968
    CAS No.
    344897-95-6

    Leukadherin 1

    Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM).

    In stock View Details
    5 mg
    $30.00
    10 mg
    $55.00
    All 7 sizes
  • KGDS
    Cat. No.
    A57452
    CAS No.
    93674-95-4

    KGDS

    KGDS is a synthetic peptide that acts as an activator of the GPIIb-IIIa integrin, which is found on the surface of activated human platelets. Its amino acid sequence, Lys-Gly-Asp-Ser, is critical for promoting platelet aggregation. This reagent is useful in studies investigating platelet function, thrombosis, and hemostasis, serving as a valuable tool for researchers examining cardiovascular diseases and related therapies.

    In stock View Details
    1 mg
    $100.00
    5 mg
    $230.00
    All 3 sizes

2 Items

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