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Integrin

Integrin inhibitors block the heterodimeric adhesion receptors that link the extracellular matrix to the cytoskeleton. Each integrin pairs one alpha and one beta subunit, and signals pass across the membrane in both directions. Many integrins recognize the arginine-glycine-aspartate (RGD) sequence, first identified as the cell attachment site of fibronectin. RGD (Arg-Gly-Asp) Peptides and the cyclic peptide cilengitide compete for this site on αvβ3 and αvβ5. Firategrast antagonizes α4β1 and α4β7, integrins involved in leukocyte trafficking. Tirofiban hydrochloride hydrate blocks the platelet integrin αIIbβ3, also known as glycoprotein IIb/IIIa. Obtustatin, a snake venom disintegrin, selectively inhibits the collagen receptor α1β1.

2 Items

  • α7β1 integrin modulator-1
    Cat. No.
    A57430
    CAS No.
    849121-82-0

    α7β1 integrin modulator-1

    α7β1 integrin modulator-1 is a potent modulator of the α7β1 integrin, a crucial receptor involved in cell adhesion and signaling. This compound shows promise in enhancing muscle regeneration and function, making it a valuable tool for research into muscular dystrophy and related muscle-wasting diseases. Its modulatory effects on integrin activity may elucidate mechanisms underlying muscular disorders and aid in the development of therapeutic strategies.

    In stock View Details
    5 mg
    $35.00
    10 mg
    $55.00
    All 4 sizes

2 Items

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