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(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P

NK1 Receptor Antagonist

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective antagonist of the neurokinin-1 (NK1) receptor. It exhibits significant biological activity by inhibiting NK1 receptor-mediated signaling pathways, which play a crucial role in pain perception, inflammation, and neurogenic responses. This compound is valuable for research in neurobiology, cancer therapy, and the development of analgesics targeting the NK1 receptor.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	115760-58-2
Applications	NK1 Receptor Antagonist
Formula	C₆₇H₁₀₂N₂₀O₁₃S
Molecular Weight	1427.72
SMILES	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)[C@H](N)CCCNC(N)=N)C(N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.