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D-Pro2,D-Trp7,9 Substance P

Catalog No.: A62124
Substance P Antagonist
[D-Pro2,D-Trp7,9] Substance P is a selective antagonist of the neuropeptide Substance P, targeting the neurokinin-1 (NK1) receptor. This compound exhibits weak agonistic properties while demonstrating potent competitive antagonism, making it useful in research applications aimed at studying pain modulation, neuroinflammatory responses, and anxiety pathways. Its unique structural modifications facilitate investigations into neurokinin signaling and potential therapeutic interventions.
[D-Pro2,D-Trp7,9] Substance P 80434-86-2 Substance P Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[D-Pro2,D-Trp7,9] Substance P is a selective antagonist of the neuropeptide Substance P, targeting the neurokinin-1 (NK1) receptor. This compound exhibits weak agonistic properties while demonstrating potent competitive antagonism, making it useful in research applications aimed at studying pain modulation, neuroinflammatory responses, and anxiety pathways. Its unique structural modifications facilitate investigations into neurokinin signaling and potential therapeutic interventions.
Product Information
Catalog NumA62124
FormulaC74H106N20O13S
Molecular Weight1515.82
CAS Number80434-86-2
Sequence shorteningRPKPQQWFWLM-NH2
SMILESCSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
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GPCR/G Protein > Neurokinin Receptors