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D-Pro2,D-Trp7,9 Substance P

Substance P Antagonist

[D-Pro2,D-Trp7,9] Substance P is a selective antagonist of the neuropeptide Substance P, targeting the neurokinin-1 (NK1) receptor. This compound exhibits weak agonistic properties while demonstrating potent competitive antagonism, making it useful in research applications aimed at studying pain modulation, neuroinflammatory responses, and anxiety pathways. Its unique structural modifications facilitate investigations into neurokinin signaling and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	80434-86-2
Applications	Substance P Antagonist
Formula	C₇₄H₁₀₆N₂₀O₁₃S
Molecular Weight	1515.82
SMILES	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.