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D-Pro4,D-Trp7,9,Nle11 Substance P (4-11)

NK1 Antagonist

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent antagonist of the neurokinin NK1 receptor. This peptide effectively inhibits the biological activities of substance P (SP) and gold-protein-substance P (GPSP), making it a valuable tool for research on pain signaling and neurogenic inflammation. Its application in studying the modulation of neurokinin-related pathways provides insights into potential therapeutic targets for various neuropsychiatric and inflammatory conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	89430-34-2
Applications	NK1 Antagonist
Formula	C₅₈H₇₇N₁₃O₁₀
Molecular Weight	1116.31
SMILES	C([C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@@H](CCCC)C(N)=O)=O)CC(C)C)=O)=O)=O)NC([C@@H](NC([C@@H](NC(=O)[C@H]4CCCN4)CCC(N)=O)=O)CCC(N)=O)=O)C=5C=6C(NC5)=CC=CC6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.