D359-0396 is an orally active inhibitor of the NLRP3 inflammasome. This compound effectively inhibits pyroptosis and the release of IL-1β in macrophages by preventing the oligomerization of NLRP3 and ASC, as well as the cleavage of GSDMD. D359-0396 has demonstrated therapeutic potential in experimental autoimmune encephalomyelitis (EAE) and enhances survival rates in murine models of septic shock. This reagent is suitable for research applications focused on inflammation and immune response modulation.
D359-0396 is an orally active inhibitor of the NLRP3 inflammasome. This compound effectively inhibits pyroptosis and the release of IL-1β in macrophages by preventing the oligomerization of NLRP3 and ASC, as well as the cleavage of GSDMD. D359-0396 has demonstrated therapeutic potential in experimental autoimmune encephalomyelitis (EAE) and enhances survival rates in murine models of septic shock. This reagent is suitable for research applications focused on inflammation and immune response modulation.
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