Fig. 1 · Structure
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D359-0396
NLRP3 Inflammasome Inhibitor
D359-0396 is an orally active inhibitor of the NLRP3 inflammasome. This compound effectively inhibits pyroptosis and the release of IL-1β in macrophages by preventing the oligomerization of NLRP3 and ASC, as well as the cleavage of GSDMD. D359-0396 has demonstrated therapeutic potential in experimental autoimmune encephalomyelitis (EAE) and enhances survival rates in murine models of septic shock. This reagent is suitable for research applications focused on inflammation and immune response modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1031977-31-7 |
| Applications | NLRP3 Inflammasome Inhibitor |
| Formula | C24H24N4O2 |
| Molecular Weight | 400.47 |
| SMILES | O=C1C2=CN3C4=C(NC(C3=C2N(C)C(N1C)=O)C5=CC=C(C(C)C)C=C5)C=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.