DAla4 Substance P (4-11)

Catalog No.: A62036
Analog of Substance P
[DAla4] Substance P (4-11) is an analog of Substance P that primarily targets neurokinin-1 receptors. It exhibits inhibitory activity against the binding of 125I-Bolton Hunter-conjugated Eledoisin and 125I-Bolton Hunter-conjugated Substance P to rat brain cortex membranes, with IC50 values of 0.5 μM and 0.15 μM, respectively. This compound is valuable for research into neuropeptide signaling, pain modulation, and related neurological pathways.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[DAla4] Substance P (4-11) is an analog of Substance P that primarily targets neurokinin-1 receptors. It exhibits inhibitory activity against the binding of 125I-Bolton Hunter-conjugated Eledoisin and 125I-Bolton Hunter-conjugated Substance P to rat brain cortex membranes, with IC50 values of 0.5 μM and 0.15 μM, respectively. This compound is valuable for research into neuropeptide signaling, pain modulation, and related neurological pathways.
Product Information
Catalog NumA62036
FormulaC44H65N11O10S
Molecular Weight940.12
CAS Number81381-50-2
Sequence shortening{D-Ala}-QQFFGLM-NH2
SMILESCSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](C)N)C(N)=O
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