Fig. 1 · Structure

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DAMPA methyl ester

Dihydrofolate Reductase Inhibitor

DAMPA methyl ester is a potent inhibitor of dihydrofolate reductase (DHFR), an enzyme critical for DNA synthesis and cell proliferation. This compound has significant implications in cancer research, particularly in the investigation of chemotherapy mechanisms. It serves as a valuable tool for studying the inhibition of folate metabolism and understanding its role in tumor growth and treatment resistance.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 23853-09-0
Applications Dihydrofolate Reductase Inhibitor
Formula C16H17N7O2
Molecular Weight 339.35
SMILES
O=C(OC)C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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