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Dapitant

Neurokinin Receptor

Dapitant is a non-peptide antagonist targeting the neurokinin-1 (NK1) receptor, demonstrating high affinity for the human receptor. By inhibiting the binding of Substance P to NK1 receptors, Dapitant effectively blocks neurokinin-mediated biological effects. This compound serves as a potential therapeutic candidate for various conditions associated with Substance P, including neurogenic inflammation and pain modulation, making it valuable for research in pain management and inflammatory disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	153438-49-4
Applications	Neurokinin Receptor
Formula	C₃₇H₃₉NO₄
Molecular Weight	561.71
Synonyms	RPR 100893
SMILES	COC1=CC=CC=C1[C@]2(O)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)[C@]5([H])[C@@]2([H])CN(C([C@@H](C)C6=C(OC)C=CC=C6)=O)C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.