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DDL-357

Catalog No.: A79334
Secreted Clusterin Enhancer
DDL-357 is a potent enhancer of secreted clusterin, targeting key pathways involved in neurodegenerative processes. It effectively reduces levels of phosphorylated tau in the brain, contributing to memory improvement in the murine 3xTg-AD model. This compound is a valuable tool for researching therapeutic strategies in Alzheimer's disease and related cognitive disorders.
DDL-357 3077900-08-1 Secreted Clusterin Enhancer
Grouped product items
Size Price Stock Qty
5mg
$185.00
In stock
10mg
$300.00
In stock
25mg
$540.00
In stock
50mg
$785.00
In stock
100mg
$1,110.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDDL-357 is a potent enhancer of secreted clusterin, targeting key pathways involved in neurodegenerative processes. It effectively reduces levels of phosphorylated tau in the brain, contributing to memory improvement in the murine 3xTg-AD model. This compound is a valuable tool for researching therapeutic strategies in Alzheimer's disease and related cognitive disorders.
Product Information
Catalog NumA79334
FormulaC22H21ClN4O2S
Molecular Weight440.95
CAS Number3077900-08-1
SMILESCC1=NN=C2[C@H](CC(OC3CC3)=O)N=C(C4=CC=C(Cl)C=C4)C5=C(SC(C)=C5C)N21
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Neuronal Signaling > Tau Protein