Fig. 1 · Structure
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DEAE-dextran, MW 500000 hydrochloride
Nucleic Acid Complexing Agent
DEAE-dextran, MW 500000 hydrochloride, is a high-molecular-weight, positively charged polymer that functions as an effective nucleic acid complexing agent. Its primary mechanism enhances the uptake of viral RNA in tissue culture cells, making it suitable for applications in gene delivery systems. When utilized in RNA-splenocyte transfer for tumor immunity, DEAE-dextran has demonstrated the ability to extend the lifespan of tumor-bearing animals, achieving results comparable to actively immunized subjects. Additionally, it can be employed as a coating agent for liposomes, facilitating various research applications in molecular biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 9064-91-9 |
| Applications | Nucleic Acid Complexing Agent |
| Molecular Weight | 500000 (Average) |
| Synonyms | DEAE-dextran; MW 500000 (hydrochloride); from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran; MW 500000 hydrochloride |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.