Decitabine

Catalog No.: A10292

DNA Methyltransferase Inhibitors

Decitabine

Decitabine Chemical Structure

CAS NO. 2353-33-5

Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase.

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$70.00
50 mg
$100.00
100 mg
$130.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Borbála Szabó, .et al. Demethylation status of somatic DNA extracted from pituitary neuroendocrine tumors indicates proliferative behavior, J Clin Endocrinol Metab, 2020, Jun 1;105(6):dgaa156 PMID: 32232382
  • Bracha Shraibman, .et al. Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy, Mol Cell Proteomics, 2016, Sep; 15(9): 3058-3070 PMID: 27412690
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Biological Activity

Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase.
Targets
DNA methylation (HL-60, KG1a cells)
In vitro (25°C) DMSO 44 mg/mL (192.8 mM)
Water 10 mg/mL (43.81 mM)
Ethanol Insoluble
In vivo water 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 43.82 mL 219.11 mL 438.21 mL
0.5 mM 8.76 mL 43.82 mL 87.64 mL
1 mM 4.38 mL 21.91 mL 43.82 mL
5 mM 0.88 mL 4.38 mL 8.76 mL

*The above data is based on the productmolecular weight 228.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10292
Actions Inhibitor
CAS No. 2353-33-5
Formula C8H12N4O4
M. Wt 228.2
Solubility DMSO
Purity >98%
Synonyms Dacogen
SMILES C1[[email protected]@H]([[email protected]](O[[email protected]]1N2C=NC(=NC2=O)N)CO)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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