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(±)-Dehydroaltenusin (racemic Dehydroaltenusin)

Pol α Inhibitor

(±)-Dehydroaltenusin is a selective inhibitor of eukaryotic DNA polymerase α (pol α), exhibiting an IC50 value of 0.68 μM. Isolated from the fungus Alternaria tenuis, it acts by competitively inhibiting the DNA template primer (Ki: 0.23 μM) and non-competitively suppressing the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). This compound is known to induce S-phase cell cycle arrest and apoptosis in cancer cells, making it a valuable reagent for research in human adenocarcinoma and related cancers.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	34279-44-2
Applications	Pol α Inhibitor
Formula	C₁₅H₁₂O₆
Molecular Weight	288.25
SMILES	O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)C1(C)OC3=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.