Fig. 1 · Structure
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Deoxyneocryptotanshinone
BACE1 Inhibitor
Deoxyneocryptotanshinone is a potent BACE1 (Beta-secretase) inhibitor, exhibiting a high affinity with an IC50 value of 11.53 μM. In addition to its primary targeting of BACE1, it demonstrates dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 133.5 μM. This compound is valuable for research applications related to Alzheimer's disease, offering insights into potential therapeutic strategies for neurodegenerative conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 27468-20-8 |
| Applications | BACE1 Inhibitor |
| Formula | C19H22O3 |
| Molecular Weight | 298.38 |
| SMILES | O=C1C(C(C)C)=C(O)C(C2=C1C=CC3=C2CCCC3(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.