Fig. 1 · Structure
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Desfluoro-ezetimibe
Cholesterol Absorption Inhibitor
Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe, which acts as an effective cholesterol absorption inhibitor. It functions primarily by targeting the Niemann-Pick C1-like1 (NPC1L1) protein, thereby reducing intestinal cholesterol uptake. This compound is utilized in research focused on lipid metabolism, cardiovascular health, and the mechanistic study of Nrf2 pathway activation in relation to cholesterol homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 302781-98-2 |
| Applications | Cholesterol Absorption Inhibitor |
| Formula | C24H22FNO3 |
| Molecular Weight | 391.43 |
| SMILES | O=C1N(C2=CC=CC=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.