Desmethyl-YM-298198 hydrochloride is a selective and noncompetitive antagonist of the metabotropic glutamate receptor 1 (mGluR1), with an IC50 value of 16 nM. This compound exhibits notable analgesic effects in mouse models of hyperalgesia induced by Streptozotocin. Its unique mechanism of action makes it a valuable tool for research into pain modulation and the role of mGluR1 in neurological disorders.
Desmethyl-YM-298198 hydrochloride is a selective and noncompetitive antagonist of the metabotropic glutamate receptor 1 (mGluR1), with an IC50 value of 16 nM. This compound exhibits notable analgesic effects in mouse models of hyperalgesia induced by Streptozotocin. Its unique mechanism of action makes it a valuable tool for research into pain modulation and the role of mGluR1 in neurological disorders.
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