Desmethyl-YM-298198 is a high-affinity, selective noncompetitive antagonist of the metabotropic glutamate receptor 1 (mGluR1), exhibiting an IC50 value of 16 nM. This compound demonstrates significant analgesic properties in models of neuropathic pain, specifically in Streptozotocin-induced hyperalgesia. It serves as a valuable tool in research aimed at understanding the role of mGluR1 in pain modulation and the development of therapeutic strategies for pain disorders.
Desmethyl-YM-298198 is a high-affinity, selective noncompetitive antagonist of the metabotropic glutamate receptor 1 (mGluR1), exhibiting an IC50 value of 16 nM. This compound demonstrates significant analgesic properties in models of neuropathic pain, specifically in Streptozotocin-induced hyperalgesia. It serves as a valuable tool in research aimed at understanding the role of mGluR1 in pain modulation and the development of therapeutic strategies for pain disorders.
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