Fig. 1 · Structure
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Desmethyl-YM-298198
mGluR1 Antagonist
Desmethyl-YM-298198 is a high-affinity, selective noncompetitive antagonist of the metabotropic glutamate receptor 1 (mGluR1), exhibiting an IC50 value of 16 nM. This compound demonstrates significant analgesic properties in models of neuropathic pain, specifically in Streptozotocin-induced hyperalgesia. It serves as a valuable tool in research aimed at understanding the role of mGluR1 in pain modulation and the development of therapeutic strategies for pain disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 299901-57-8 |
| Applications | mGluR1 Antagonist |
| Formula | C17H20N4OS |
| Molecular Weight | 328.43 |
| SMILES | O=C(C1=C(C)N2C3=CC(N)=CC=C3N=C2S1)NC4CCCCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.