Fig. 1 · Structure
Documents & Downloads
DFL23448
Cat. No.
A68852
CAS
1445753-16-1
TRPM8 Antagonist
DFL23448 is a selective antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. It demonstrates potent inhibition with IC50 values of 10 nM and 21 nM in human embryonic kidney 293 cells stimulated by Cooling Agent 10 or cold exposure. DFL23448 exhibits minimal activity against other transient receptor potential channels, such as TRPV1, TRPA1, and TRPV4, as well as various G protein-coupled receptors. This compound has potential applications in modifying bladder function and alleviating bladder overactivity in in vivo models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1445753-16-1 |
| Applications | TRPM8 Antagonist |
| Formula | C12H10FN5OS |
| Molecular Weight | 291.30 |
| SMILES | OC1=C(C2=NN(CC)N=N2)SC(C3=CC=CC(F)=C3)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.