DFL23448 is a selective antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. It demonstrates potent inhibition with IC50 values of 10 nM and 21 nM in human embryonic kidney 293 cells stimulated by Cooling Agent 10 or cold exposure. DFL23448 exhibits minimal activity against other transient receptor potential channels, such as TRPV1, TRPA1, and TRPV4, as well as various G protein-coupled receptors. This compound has potential applications in modifying bladder function and alleviating bladder overactivity in in vivo models.
DFL23448 is a selective antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. It demonstrates potent inhibition with IC50 values of 10 nM and 21 nM in human embryonic kidney 293 cells stimulated by Cooling Agent 10 or cold exposure. DFL23448 exhibits minimal activity against other transient receptor potential channels, such as TRPV1, TRPA1, and TRPV4, as well as various G protein-coupled receptors. This compound has potential applications in modifying bladder function and alleviating bladder overactivity in in vivo models.
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