Fig. 1 · Structure
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DG-041
EP3 Receptor Antagonist
DG-041 is a potent and selective antagonist of the EP3 receptor, exhibiting high affinity with IC50 values of 4.6 nM in binding assays and 8.1 nM in FLIPR assays. This compound effectively inhibits prostaglandin E2 (PGE2)-induced facilitation of platelet aggregation, making it valuable in studies related to platelet function and cardiovascular research. Additionally, DG-041's ability to cross the blood-brain barrier enhances its potential applications in neuroscience and related fields.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 861238-35-9 |
| Applications | EP3 Receptor Antagonist |
| Formula | C23H15Cl4FN2O3S2 |
| Molecular Weight | 592.32 |
| SMILES | O=C(NS(=O)(C1=CC(Cl)=C(Cl)S1)=O)/C=C/C2=CC(F)=CC3=C2N(CC4=CC=C(Cl)C=C4Cl)C=C3C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.