Fig. 1 · Structure
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DH-376
Diacylglycerol Lipase Inhibitor
DH-376 is a potent diacylglycerol lipase inhibitor, exhibiting pIC50 values of 8.6 for ABHD6 and 8.9 for DAGLα. This compound is effective in preventing fasting-induced refeeding in murine models. Additionally, DH-376 serves as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating diverse applications in chemical biology and bioconjugation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1848233-57-7 |
| Applications | Diacylglycerol Lipase Inhibitor |
| Formula | C31H28F2N4O3 |
| Molecular Weight | 542.58 |
| SMILES | O=C(N1N=CC(C(C2=CC=C(F)C=C2)(C3=CC=C(F)C=C3)O)=N1)N4[C@@H](CC5=CC=CC=C5)CC[C@@H](OCC#C)C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.