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DHODH-IN-29

Dihydroorotate Dehydrogenase Inhibitor

DHODH-IN-29 is a covalent inhibitor targeting Dihydroorotate Dehydrogenase (DHODH) in Leishmania braziliensis, exhibiting an IC50 value of 0.5 μM. This compound demonstrates significant potential for the development of antileishmanial therapies, making it a valuable tool in the study and treatment of leishmaniasis. Its selective inhibition of LbDHODH positions it as a key reagent for exploring therapeutic strategies against this parasitic disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	212375-00-3
Applications	Dihydroorotate Dehydrogenase Inhibitor
Formula	C₁₃H₁₀N₂O₃
Molecular Weight	242.23
SMILES	O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=CC=C2)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.