Fig. 1 · Structure
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DI-1859
DCN1 Inhibitor
DI-1859 is a potent and selective covalent inhibitor of DCN1, designed to hinder the neddylation process of cullin 3 in cellular environments at low nanomolar concentrations. This compound markedly increases NRF2 protein levels, a substrate of CRL3, in mouse liver tissues. Additionally, DI-1859 demonstrates protective effects against acetaminophen-induced hepatic injuries in murine models, highlighting its potential applications in liver protection studies and mechanistic research on the neddylation pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2247061-09-0 |
| Applications | DCN1 Inhibitor |
| Formula | C30H45N5O3S |
| Molecular Weight | 555.78 |
| SMILES | CN(C)CC(C(NC[C@H](C1CCCCC1)NC([C@@H](NC(CC)=O)CC(SC2=C3)=NC2=CC=C3C(C)C)=O)=O)=C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.